South Dakota reschedules FDA-approved crystalline polymorph psilocybin to Schedule IV

Original title: reschedule the pharmaceutical composition of crystalline polymorph psilocybin in a drug product approved by the Food and Drug Administration as a Schedule IV controlled substance.

Last action · March 10, 2026: Signed by the GovernorSponsors: Tom Pischke and 12 others

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What This Bill Does

South Dakota reclassifies the pharmaceutical composition of psilocybin in an FDA-approved drug product from Schedule I to Schedule IV, easing state restrictions for medical use.

Why it matters

Alters the legal availability and prescription framework for specific FDA-approved psilocybin-based pharmaceutical treatments within the state.

Who It Affects

Groups the bill's text affects, as described in the record. Being affected is not a position for or against it.

Directly affected

Medical patients

Patients may gain legal access to specific FDA-approved psilocybin pharmaceutical treatments under Schedule IV regulations.

Directly affected

Healthcare providers

Providers are subject to updated prescribing and handling rules corresponding to Schedule IV controlled substances.

Key Facts

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Frequently Asked Questions

Does this bill legalize all forms of psilocybin in South Dakota?

No. Only the specific pharmaceutical composition of psilocybin contained in an FDA-approved drug product is rescheduled to Schedule IV. All other forms of psilocybin remain strictly controlled under Schedule I.

What schedule is crystalline polymorph psilocybin moved to?

It is moved from Schedule I to Schedule IV under South Dakota controlled substances law.

What else do you want to know?

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Where This Stands

Current status: Signed into law.

Procedural history

14 actions

Mar 10, 2026HouseEnrolled
Signed by the Governor
Mar 5, 2026HouseEnrolled
Delivered to the Governor
Mar 4, 2026Senate
Signed by the President
Mar 3, 2026House
Signed by the Speaker
Mar 2, 2026SenateFloor
Do Pass
Feb 26, 2026Senate
Remove from Consent Calendar

Show 8 earlier actions

Feb 25, 2026Senate
Certified uncontested, placed on consent
Feb 25, 2026SenateCommittee
Do Pass
Feb 25, 2026Senate
Scheduled for hearing
Feb 10, 2026SenateIntroduced
First read in Senate and referred to
Feb 9, 2026HouseFloor
Do Pass
Feb 5, 2026HouseCommittee
Do Pass
Feb 5, 2026House
Scheduled for hearing
Jan 21, 2026HouseIntroduced
First read in House and referred to

Version history

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